Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics

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Enhanced peripheral leukocyte leukotriene production and bronchial hyperresponsiveness in asthmatics.

Leukotrienes (LTs) are pro-inflammatory mediators that contribute to the pathophysiological features of asthma. The relationship between the amounts of LTB4 and LTC4 produced by the leukocytes of asthmatic patients on the one hand and immunoglobulin E (IgE)-mediated allergy, asthma exacerbations and bronchial hyperresponsiveness was studied. Leukocytes were obtained from peripheral blood drawn ...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2000

ISSN: 0903-1936,1399-3003

DOI: 10.1034/j.1399-3003.2000.016003504.x